KromaTiD offers a full range of dGH and Pinpoint FISH assay services, ranging from detecting specific DNA rearrangements in your samples to partnering with you to screen the entire genome for clinically important mutations.
In addition to our catalog of standard assays, we specialize in quickly and efficiently designing custom assays to your specifications. You provide the samples—culture, tissue or blood—we design, build, validate and perform the assays, providing you with comprehensive reporting.
We will identify inversions,translocations, and other mutations in your area of interest, and provide analysis and reporting of the results. Benefits include:
Rapid assay development and data delivery
Cost effective discovery of inversions and translocations
Sequence, location and orientation from a single assay
High resolution screening of individual genes to the entire genome
dGH Platform Variants
The dGH platform is available in three general varieties. Each platform variation has broad utility in multiple fields and can be used to identify structural abnormalities of varying sizes in metaphase or interphase cells. From the de novo discovery of large rearrangements, to specific targets as small as 5kb, the versatility of dGH provides researchers with structural genomic insight at almost any level.
1. dGH Chromatid Paints
KromaTiD’s full chromosome chromatid paints can be used to screen the full genome, whole chromosomes, or even single arms or regions of chromosomes for clinically important DNA rearrangements. dGH paints can be used for the de novo discovery of all manner of structural variations including inversions, sister chromatid exchanges, translocations, and copy number variants.
2. Targeted dGH
Targeted dGH provides insight into structural aberrations occurring in specific regions of the genome. Capable of discovering both small and large structural rearrangements, targeted dGH is a versatile method that helps researchers gain a deeper understanding about structural abnormalities in almost any region of interest.
3. Pinpoint FISH
Pinpoint FISH was developed with precision and resolution in mind. With 3x the relative signal of BAC FISH probes, and the ability to hit targets as small as 4kb in length, Pinpoint FISH can be used to detect inversions, gene rearrangements, gene fusions, copy number variants, duplications or deletions at nearly any location of the genome.
To learn more about dGH platform variants and their applications, check out our research page, product pages, or get started with our simple three step process below.