dGH fits into the DNA mis-repair analysis workflow as an orthogonal and complementary technique to next generation sequencing. dGH can be employed at multiple experimental timepoints:
Pre-damage: dGH provides a measurement of pre-existing or ‘baseline’ structural variation which is unique to each model, person and cell line. dGH can also be used for process optimization by monitoring the effects of differing process variables on your experimental system.
Post-damage: dGH can measure structural rearrangements at multiple time points immediately following DNA damage and it can be used to track the persistence of measured variants over time.
From establishing a baseline structural variation rate, to measuring DNA damage-associated changes, to tracking genomic integrity after treatment, dGH provides a comprehensive structural genomic profiling technique which helps to ensure that any genomic rearrangements are accounted for.