Why Monitor Delivery?
Cellular damage induced by reagent delivery conditions can result in unintended genomic structural rearrangements. Tracking these rearrangements is critical to a comprehensive understanding of all the stressors on your cell population.
dGH provides an extremely simple and precise method for the detection and quantitation of all manner of genomic structural rearrangements. This includes translocations, copy number variants and previously undetectable inversions that sequencing and other pooled DNA bioinformatic methods miss.
Using dGH to Establish a Structural Error-Free Cell Rate (SEFC)
dGH is used on a sample of cells before delivery is performed to establish a baseline structural error-free cell rate. After delivery, dGH is used on a sample from the treated population to detect and quantitate any variations from the baseline rate.
dGH Delivery Products and Services
KromaTiD offers both dGH products and services for seamless incorporation into your delivery process. Contact us to discuss your project with our team of experts today!
- Pre-Delivery dGH. Use dGH on a sample from the target cell population in order to establish a baseline structural error free cell rate. 2. Delivery. Perform delivery on a sample from the target cell population using your delivery method of choice. 3. Post-Delivery dGH. Use dGH on a sample from the delivery experiment cell population to determine variation from the baseline structural error free cell rate.