KromaTiD Chromatid PaintsAn assortment of human maladies ranging from autism and hypertension to infertility and cancer are associated with chromosomal rearrangements that “flip” a broken piece of DNA around and “fix” it back into the chromosome. Termed inversions, these rearrangements constitute perhaps the largest group of undetected chromosome aberrations, due mainly to limitations imposed by current methodologies; i.e., small inversions are invisible. Thus, the significance of inversions in genetic disease is almost certainly greatly under appreciated. KromaTiD holds the key to improving detection of previously “cryptic” inversions, thereby unlocking their potential and promise for improving our understanding of currently unknown changes that underlie congenital disorders and disease. KromaTiD’s proprietary chromatid paint technology takes advantage of cutting-edge genomics and bioinformatics strategies to advance our ability of detecting even the smallest of inversions. Chromatid paint development will serve to enable novel gene discovery, facilitating new molecular diagnostics and identification of new therapeutic targets, bringing individualized medicine and therapy closer to reality. |
KromaTiD recently completed its first chromatid paint, specific for chromosome 3 (image). The strand-specific/single-sided nature of the fluorescent paint is readily appreciated.
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