KromaTiD’s Dark Lab Files: A Blog
Boosting CAR-T Cell Therapy with ICIs
Immune checkpoint inhibitors (ICIs) are a class of molecules that target specific biochemical pathways involved in regulating immune responses. These pathways, known as immune checkpoints, play a critical role in modulating the activity of immune cells, particularly T cells, to prevent inappropriate responses to [...]
Avidity, Affinity, and B7H3 as a Cancer Cell Marker
Successful targeting of cell-surface tumor markers by various methods has made identification of such molecules a potentially high pay-off goal for the creation of new anti-cancer therapies. These treatments include antibody-based approaches and adoptive immunotherapies like chimeric antigen receptor, CAR-T cell products. One attractive [...]
New Research Characterizes Optical Genome Mapping False-Negative Risk
Optical Genome Mapping (OGM) is a technology which employs microfluidics, image analysis, and high-resolution microscopy to detect structural variations (SVs). The process begins with the isolation of high molecular weight DNA from biological samples. This DNA is then fluorescently labeled, counterstained, and loaded onto [...]
Advancements and Challenges in CAR T-Cell Therapy for Myeloid Malignancies
Great strides have been made in the treatment of B-cell malignancies with Chimeric antigen receptor (CAR) T-cell therapies. Efforts have been less successful when applying the technology to myeloid malignancies. Research published this year focusing on AML showcases the challenges.1 Myeloid malignancies, characterized by [...]
CB-011: A Gene-Edited CAR-T Therapy Against Multiple Myeloma
Multiple myeloma (MM) is a complex blood cancer affecting plasma cells. Patients can experience bone damage and fractures, kidney failure resulting from protein buildup, anemia and more frequent infections, among other symptoms. Given the disease's serious impacts to quality and length of life, scientists [...]
Genomic Insights into Cancer from the 100,000 Genomes Cancer Program
The 100,000 Genomes Cancer Program is a UK government research initiative aimed at integrating genomic data with clinical information to gain insights into the molecular basis of cancer. It involves the sequencing of genomes from 100,000 cancer patients, encompassing a diverse range of cancer [...]